Describe with the aid of examples two different techniques for phylogeny
What are the usage and the limitations of the Bootstrap technique in phylogeny?
March 21, 2023Why do we use dynamic programming algorithms for sequence alignment problems?
March 21, 2023Describe with the aid of examples two different techniques for phylogeny
COMPUTER SCIENCE TRIPOS Part II – 2012 – Paper 7
Bioinformatics (PL)
(a) Considerable recent Bioinformatics research has focused on phylogenetics.
(i) What is the motivation for this work? [1 mark]
(ii) Describe with the aid of examples two different techniques for phylogeny.
In each case discuss the issues of complexity and performance.
[4 marks each]
(b) Considerable recent Bioinformatics research has focused on structure prediction
from sequence data.
(i) Describe how you would build a hidden Markov model (HMM) to identify
membrane segments in aminoacid sequences. [6 marks]
(ii) How you would assess the sensitivity and specificity performance of your
HMM? [5 marks]
