Adenosine monophosphate deaminase 1 deficiency

Instructions

Hello
I need this assignment for Metabolism unit. I have attached Word.DOC files with all points I want for this assignment.

Assignment ( Adenosine monophosphate deaminase 1 deficiency )

2000 words

Metabolic Disorders : from the list provided, addressing the current Research (R), Diagnosis (D), Treatment (T) and Policy (P)

Assignment Part A – Metabolic Disorders.

Many organisms carry and express genetic mutations that alter the metabolism of the cell, in some cases resulting in disorders which can be debilitating and/or life threatening. Plants, vertebrates and invertebrates obtain substrates for energy and building blocks, however, some compounds alter energy metabolism (increasing or decreasing rate and/or efficiency).

You should include a brief outline of the analysis method(s) used to detect or confirm the condition, from the topic list provided.

– Research will address the current research, published in scientific journals, regarding the topic or condition.
– Diagnosis will address the current diagnostics applied to the topic or condition.
– Treatment will address the current treatment options relevant to the topic or condition.

– Policy will address the current policies/legislation (federal, state or international) relevant to the topic or condition (e.g. adverse health outcomes or legislation for drug use).

You will be assessed on the following:

The Assignment must use the Headings (in bold) below and address the following:

1. Overview

Identify the name(s), class and structure of the ‘Metabolic Disorder’ molecule and contextualize the intracellular metabolic biochemical pathways they affect (i.e. Protein, Carbohydrate and/or Lipid). Briefly outline the effect(s) the Disorder has on the organism locally (i.e. specific cells or tissue) and/or as a whole (i.e. the whole organism). Identify the Substrates/Precursors and the biochemical steps to produce the Disorder (i.e. parent molecule, key enzymes & cofactors involved in synthesis) and describe the transport, half-life, receptor activation and fate following action – Disorder effect within the cell/organism. Describe the biochemical pathway(s) (i.e. Protein, Carbohydrate and/or Lipid), the selected Disorder alters, including key enzymes/cofactors and intermediates directly affected.

2. Research

Describe the most recent research (published scientific article(s)) effort pertaining to the Disorder. This may include, but not limited to, characterization of metabolic status, biochemical pathways, receptors and signal transduction within cells or tissue and the identification of potential therapeutic(s).

3. Diagnosis

Identify the disease state(s)/or consequence(s) of the Disorder that arise if there is a genetic defect in the metabolic /biosynthetic pathway of target cells/tissues.

4. Treatment

Describe the current treatment(s)/strategy(ies), approved for use, to overcome the disease state as a consequence of Disorder. Comment on, with the aid of statistical information, the change in prognosis as a consequence of treatment.

5. Policy

Outline the current policies/legislation (federal, state or international) relevant to the Disorder (e.g. adverse health outcomes or legislation for therapeutic use).

Report Format.

Diagrams maybe used (with appropriate references). The report should be in 12pt font, <2,000 words, with Vancouver referencing format (labelled as superscript numbers throughout the text and identified in the References, Website(s) should include accession dates).

Note: References and diagram/legends are not included in the word count.