Explain with one example the difference between local and global alignment
Discuss how to efficiently cluster a set of gene expression data
March 21, 2023Describe the differences between Soft and Hard Clustering
March 21, 2023Explain with one example the difference between local and global alignment
COMPUTER SCIENCE TRIPOS Part II – 2018 – Paper 7
Bioinformatics (PL)
(a) Explain with one example the difference between local and global alignment.
[3 marks]
(b) Give one example why the multiple alignment, as implemented in the software
Clustal, described in the course, needs a guide tree. [4 marks]
(c) What is the scope of phylogeny? [2 marks]
(d) Describe the UPGMA algorithm. [4 marks]
(e) Explain with one example what the ultrametric property of a phylogenetic tree
tells us about the evolutionary process. [3 marks]
(f ) Explain the steps and the complexity of the divide and conquer approach to
sequence analysis. [4 marks]
