Human Biology

Example human biology dissertation topic 1:

Contribution of ion channel mutations to neuro-degeneration

Evidence continues to suggest that mutations within ion channels are a significant contributor to neuro-degenerative diseases, such as epilepsy. Continued investigation of the phenomenon offers the possibility of treatment and even prevention of such conditions in the future. This dissertation explores the activation of acid-sensing ion channels by protons, and the subsequent pathological processes, with a particular emphasis on acidosis-mediated neuronal injury. The study undertakes a thorough and in-depth analysis of the existing literature on the topic and presents a synthesis of current academic progress, including the present state of development of ant-epileptic medications.

Suggested initial topic reading:

• Armijo, J.A., Shushtarian, M., Valdizan, E.M., Cuadrado, A. Cuevas, I. and Adin, J. (2005) ‘Ion channels and epilepsy’, Current Pharmaceutical Design, Vol. 11(15), pp. 1975-2003.
• Chong, Z.G., Pignataro, G., Li, M., Chang, S-U. and Simon, R.P. (2008) ‘Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases’, Current Opinion in Pharmacology, Vol. 8(1), pp. 25-32.
• Steinlein, O.K. and Noebels, J.L. (2000) ‘Ion channels and epilepsy in man and mouse’, Current Opinion in Genetics & Development, Vol. 10(3), pp. 286-291.