Formulate Evidence-Based Practice Question: Focus on the PICOT model for guiding the development of research questions. • Reflect on an issue or problem that you have noticed in your nursing practice. Consider the significance of this issue or problem. • Generate at least five questions that relate to the issue which you have identified. Select one question that would be most appropriate in terms of significance, feasibility, and interest. Be prepared to explain your rationale. • Formulate a preliminary PICO question—one that is answerable—based on your analysis. What are the PICO variables (patient/population, intervention/issue, comparison, and outcome) for this question? Note: Not all of these variables may be appropriate to every question. Be sure to analyze which are and are not relevant to your specific question. • Using the PICOT variables that you determined for your question, develop a list of at least 10 keywords that could be used when conducting a literature search to investigate current research pertaining to the question. To complete: Write a 3- to 4-page paper that includes the following: • A summary of your area of interest, an identification of the problem that you have selected, and an explanation of the significance of this problem for nursing practice • The 5 questions you have generated and a description of how you analyzed them for feasibility • Your preliminary PICOT question and a description of each PICOT variable relevant to your question • At least 10 possible keywords that could be used when conducting a literature search for your PICOT question and a rationale for your selections